Knee cartilage growth after autologous-adipose stem cell injection

Home → More evidence of knee cartilage growth after Adipose Biocellular tissue injection

Demonstrated cartilage growth on MRI 3 weeks after Autologous Adipose stem cell injection

In this study showing evidence of knee cartilage growth after autologous adipose tissue injection, Dr. Jaewoo Pak and colleagues enrolled three patients: an 87-year-old female with stage 3 OA, a 68-year-old male with stage 3 OA, and a 60-year-old female with stage 3 OA, were included. All had significant findings of advanced osteoarthritis on MRI, all had a significant disability with range of motion and walking, and all had been told their only option was total knee replacement.

All three patients were treated with autologous adipose and autologous PRP and HA at day 0. Subsequently, the patients returned to the clinic every week × 3 for HA and autologous PRP activated with calcium chloride. The patients were assessed at the weeks of 2, 4, and 16 (18 or 22) for pain improvement in terms of VAS and function improvement in terms of physical therapy parameters. In addition, these patients were followed by post-treatment MRI 3 months after the treatment. All patients demonstrated improvement in cartilage on MRI, and all patients reported greater than 75% improvement in pain and range of motion by 22 weeks.

Source

Pak J, Lee JH, Park KS, Jeong BC, Lee SH. Regeneration of Cartilage in Human Knee Osteoarthritis with Autologous Adipose Tissue-Derived Stem Cells and Autologous Extracellular Matrix. Biores Open Access. 2016;5(1):192-200. Published 2016 Aug 1. doi:10.1089/biores.2016.0024

Abstract

This clinical case series demonstrates that percutaneous injections of autologous adipose tissue-derived stem cells (ADSCs) and homogenized extracellular matrix (ECM) in the form of adipose stromal vascular fraction (SVF), along with hyaluronic acid (HA) and platelet-rich plasma (PRP) activated by calcium chloride, could regenerate cartilage-like tissue in human knee osteoarthritis (OA) patients. Autologous lipoaspirates were obtained from adipose tissue of the abdominal origin. Afterward, the lipoaspirates were minced to homogenize the ECM. These homogenized lipoaspirates were then mixed with collagenase and incubated. The resulting mixture of ADSCs and ECM in the form of SVF was injected, along with HA and PRP activated by calcium chloride, into knees of three Korean patients with OA. The same affected knees were reinjected weekly with additional PRP activated by calcium chloride for 3 weeks. Pretreatment and post-treatment magnetic resonance imaging (MRI) data, functional rating index, range of motion (ROM), and pain score data were then analyzed. All patients’ MRI data showed cartilage-like tissue regeneration. Along with MRI evidence, the measured physical therapy outcomes in terms of ROM, subjective pain, and functional status were all improved. This study demonstrates that percutaneous injection of ADSCs with ECM contained in autologous adipose SVF, in conjunction with HA and PRP activated by calcium chloride, is a safe and potentially effective minimally invasive therapy for OA of human knees.

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Neuroprolo

One of the irritating events in my body took two Oregon Regenerative Medicine doctors and one flash of insight to address, and the teamwork proved most efficacious!

My rambunctiously insomniac left calf, a disturbance identified by my chiropractor as an entrapped fibular nerve, stirringly alive in the daytime, became most troublesome at night with tremulous sensations like myriad tiny creatures humming and streaming beneath my skin, keeping me awake at night with their frenetic activity. Dr. Peterson got to work taming this insurrection with neuroprolo, a technique of light and superficial injections with effects far from superficial. I could already feel significant improvement, and enjoy deeper sleep, after the first session, and returned several times over the next few months for repeat performances till these symptoms abated completely.

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Collagen Induction

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How PRP prolotherapy cured my headache

After two years I still had a constant headache after I got a concussion by falling on my head. I was plagued by constant headaches that would not go away no matter what I did. I had x-rays, an MRI, and I tried all the drugs that several of my doctors prescribed to me. Nothing helped and I did not want to just live on drugs. I tried different massage therapist, acupuncture, a couple different chiropractors, and all sorts of natural medicines and exercises. My headache was quite severe. After over a year of constant neck and headache pain, I was finally referred to Dr. Peterson.

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Migraine headaches & hip pain

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Lorri Busse

Tehachepi, CA

Old athletic injuries healed

I am often cautious when I hear someone exclaim, “that treatment was amazing” or “what a miracle”, however, hear I am saying those same words after just a few treatments of prolotherapy from Dr. Peterson. I came in to get treatment for some old athletic injuries from a water skiing accident in 1994 and many various crashes alpine skiing, plus the usual aches and pains of being athletic. I had sustained quite a bit of trauma to my sacro-iliac joint 15 years prior to seeing Dr. Peterson in a water skiing accident and then many years of alpine skiing crashes on top of overuse injuries in weightlifting, running, cycling and mountaineering. I had pain and limitation in range of motion mainly in the sacroiliac joint area, but with many areas to include shoulder joint, knee and along my sacrum and lumbar spine. After receiving just 2 treatments, I already had significant improvements in pain and motion, plus I was getting stronger. As I continued my treatments, it was as if the injuries no longer even existed and I had new supportive ligamentous support. Now, telling my story many years later, I feel I can actually say, “wow, that was a miracle treatment by Dr. Peterson.” I have competed in various CrossFit competitions, continued to cycle even harder, continue to excel in my strength, recovery from workouts and backpack and climb for days and days without pain or dysfunction.

KL, Portland, Oregon

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Adipose tissue graft instead of hip replacement

After 3 Orthopedic surgeons told me I needed a total hip replacement, I tried prolotherapy and PRP up here in Seattle. The pain continued and had gotten severe enough that I was making plans for surgery. Then a friend told us about adipose tissue grafts, and we saw Dr. Peterson and I had my first treatment October 2013. Within 5-weeks I was having a lot less pain, and I was able to use my hip in ways I had not been able to for 5 years. Now, 8 months later I can say I’m 80-85% back to full function and use of my hip and no pain, and I’m still seeing gradual improvement. I tell everyone with a bad knee or hip or back about my results and those that have seen Dr. Peterson have all had great results.

N.E.

Seattle, Washington

Adipose tissue grafts for foot and ankle arthritis

Dear Dr. Peterson–you been a very significant influence on my health over the last 20 years, starting with finding that my digestive problems were due to low stomach acid. None of the G.I. specialists came up with anything. The initial PRP prolotherapy back in 2009–what a difference, especially noticeable in the osteoarthritis of my thumbs and knees.

Now with the addition of adipose tissue grafts and orthobiologics to the mix, my foot and ankle has healed and I actually have realistic hope of being able to hike long distances again.

Thank you for your drive, intellect, capability, etc., etc., etc. that have brought you to this level of healing ability, gratefully,

A.G., Lake Oswego

Alp Goldsmith

Lake Oswego, Oregon

ACL tear

I was having pain in both knees and thought it was just part of growing old. After a 2nd acute hyperextension injury I was told I needed surgery. I saw Dr. Peterson and unlike the orthopedist who did a quick exam and ordered an MRI, Dr. Peterson examined my knees and figured out exactly where my problem areas were. After 3 PRP treatments, I have no pain and feel completely stable. I’m confident that my 35-year-old knees will be back to where they were when I was younger. My job as a firefighter is physically demanding and I was able to remain active throughout all of my treatments. Worth every penny! Is also way better than going under the knife! Thanks Dr. Peterson!

Firefighter in Portland, Oregon

Bone-on-bone knee cartilage

34 years ago I had surgery to remove the cartilage in my knee. Gradually my activity became more and more limited and I used to plan my day around how much use I could get out of my knee. As years went by I could be on my knee for no more than 45 to 60 min. at a time and had to rest it for several hours to reduce the pain and swelling before resuming even the simplest physical activity.

I began prolotherapy with Dr. Peterson about 18 months ago, and slowly began to see the difference in leg strength, the ability to work, and reduced wobbling and swelling of 30+ years. Now I do the usual things that others may take for granted like walking, gardening, climbing a ladder, going up and down steps without pain. I will say that I’ve regained 75% to 80% of the use of my knees and I can enthusiastically encourage those who look at prolotherapy is a noninvasive procedure with proven results.

Paul Mumford

Business analyst in Salem, Oregon

Knee arthritis

I’m walking now with no pain!
Dr. Peterson-thank you so much for the prolotherapy-I feel great! I can bend my knees with no pain-squat with no pain-I am walking out with no pain!

Rachel Lewis

Retired in Milwaukie, Oregon

TMJ

I’ve had considerable stiffness and facial spasms on the left side of my face for 30 years. I read about prolotherapy in a book. Over 2-years, I’ve probably had 10 prolotherapy sessions in the TMJ, in my neck, and all down my spine. Miraculously this has healed the surgical damage I had to the nerve on the left side of my face, and I now have freedom from pain in ways no one could possibly understand. I even brought in my friend to see Dr. Peterson to repair both of his knee joints. His results were miraculous too.

Beaverton, Oregon

Sciatica & spinal stenosis

Since 2003 I’ve had intermittent sciatic pain from lumbar stenosis alongside of scoliosis. In 2008, two West Coast orthopedic surgeons offered to rebuild my spine but my friend Jean Lusk told me about her comparable medical situation resolved from PRP prolotherapy by Dr. Peterson. I agreed to 6 months treatment which lasted from February till July 2010. The conclusion is that I have achieved 80% success in relieving the pain. What I have gained has been just short of miraculous! My attending M.D. remarked that as a 75 year-old my progress was just short of a miracle!

R. Siebens

Rose Villa, Milwaukie OR

Torn hip labrum in Olympic athlete

I’ve been extremely busy since returning to the United Kingdom and my water polo team. Tomorrow will be exactly one month since my first PRP prolotherapy and my hip is definitely improving-I am very pleased with the results so far. I do still have some pain, but is less than before therapy. Sometimes it doesn’t hurt at all. I’ve played in competitions since the prolotherapy and didn’t feel my hip aching. I will be in Oregon in late December and I was hoping to get more prolotherapy on both hips in preparation for the Summer Olympics.

Lisa Gibson

British Olympic Water Polo Team

Torn hip cartilage

My name is Jene Denis, I’m 51 years old and have been an athlete all of my life. One day while running an 8-miler through the hills where live I felt my hip pop; man it hurt and I still had at least 4 miles to go. I thought my hip dislocated. I went to several doctors, most were top in their field and the diagnosis was ripped labrum cartilage in my hip, with degeneration of the cartilage and bone loss as well. The doctors were talking about hip replacement. At 51?

My Dr. here in Bend knew about Dr. Peterson’s success with hips and with each PRP injection the pain lessened and I was healing and I could not believe it. This year I skied and snowboarded all winter.

Jene Denis

Bend, OR

Sciatic Pain and Lumbar Stenosis

For eight years before seeing Dr. Peterson I had sciatic pain so incapacitating that Physical therapy did not help, and exercise was impossible as it would trigger me to be bed ridden in pain. I sought help from AMA orthopedists who diagnosed sciatica from lumbar stenosis and offered to rebuild my spine. I finally took the advice of another resident here at Rose Villa who had had success with her back and knees. After six PRP prolo treatments I achieved 80% relief of my pain, and I now exercise and take part in the activities here at Rose Villa. My attending physician remarked that my progress was “just short of a miracle”. I shall be eternally grateful to Dr. Peterson for saving me from surgery!

-Joyce Siebens, Retired, 80 years young!

Weight loss

HCG: What does this weight loss and change in diet mean for me? It’s like a rebirth. The weight was acquired so gradually, that it just snuck up on me, and I truly didn’t realize how desperately handicapped I had become. I fluffed off the limitations is just part of getting older. Well, now I am older and fat-free and feel as if I could live forever. Every move I make is a move of freedom. My mood is lighter as well, as light as my weight. The vague depression faded as I became physically lighter. I’m healthier because of the weight loss in every way my body functions. I look forward with joy to my future as a healthy, active, very happy, great-grandmother. I could not have accomplished any of this without the help of my good friend Dr. Noel Peterson. He’s been my doctor for over 12 years. His supporting and guidance kept me on the mark.

Herma Ray Baxter

Portland, OR

More evidence of knee cartilage growth after Adipose Biocellular tissue injection